ZNF707抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09682(ZNF707 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

The ZNF707 antibody is a tool used to study the ZNF707 protein, a member of the zinc finger protein (ZFP) family characterized by conserved C2H2-type zinc finger domains. These proteins typically function as transcription regulators by binding DNA or interacting with chromatin-modifying complexes. ZNF707 is implicated in epigenetic regulation, potentially influencing gene expression during development, cellular differentiation, or disease. Studies suggest it may interact with Polycomb repressive complexes (PRCs) or NuRD complexes, which are critical for maintaining chromatin states and silencing specific genes. Dysregulation of ZNF707 has been tentatively linked to cancer and neurodevelopmental disorders, though its precise biological roles remain under investigation.

The ZNF707 antibody is commonly generated in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. It enables researchers to detect ZNF707 expression in various applications, including Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Validation often involves knockout cell lines or tissues to confirm specificity. Commercial antibodies typically provide data on reactivity (human, mouse, rat), clonality (monoclonal/polyclonal), and conjugate options (e.g., HRP, FITC). As research progresses, this antibody serves as a key reagent for elucidating ZNF707's role in gene regulation networks and disease mechanisms.