DHRS7抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human kidney tissue lysate, Primary antibody: P09665(DHRS7 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09665(DHRS7 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The DHRS7 (Dehydrogenase/Reductase 7) antibody is a tool used to study the DHRS7 protein, a member of the short-chain dehydrogenase/reductase (SDR) superfamily. DHRS7. also known as retinol dehydrogenase 12 (RDH12), plays a role in retinoid metabolism by catalyzing the oxidation of retinol to retinaldehyde, a critical step in vitamin A processing. This enzyme is localized in the endoplasmic reticulum and is expressed in various tissues, including the liver, kidney, and brain. Its involvement in lipid metabolism and cellular detoxification pathways has linked it to diseases like age-related macular degeneration, neurodegenerative disorders, and certain cancers.

DHRS7 antibodies are primarily used in research applications such as Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression levels, tissue distribution, and subcellular localization. These studies help elucidate DHRS7's functional roles in physiological and pathological contexts. For example, altered DHRS7 expression has been observed in tumor tissues, suggesting its potential as a biomarker or therapeutic target. The antibody’s specificity and validation (e.g., knockout validation) are crucial for ensuring accurate experimental results. Ongoing research focuses on clarifying DHRS7's regulatory mechanisms, interaction networks, and its broader implications in metabolic diseases and cancer biology.