SLFN5抗体

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09664(SLFN5 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

Schlafen family member 5 (SLFN5) is a protein encoded by the *SLFN5* gene, part of the Schlafen family implicated in cell proliferation, differentiation, and immune regulation. SLFN5. first identified in mice, shares conserved structural features across species, including a Schlafen-specific domain and a divergent C-terminal region. It is expressed in immune cells (e.g., T cells, dendritic cells) and certain cancer cells, where it modulates transcriptional regulation, chromatin remodeling, and antiviral responses. Studies suggest SLFN5 interacts with RNA polymerase II, influencing gene expression by suppressing transcriptional elongation. Its role in immune evasion and tumor progression has drawn interest, as elevated SLFN5 levels correlate with poor prognosis in cancers like melanoma and breast cancer.

SLFN5-specific antibodies are critical tools for studying its expression, localization, and molecular interactions. These antibodies (monoclonal or polyclonal) are typically generated using immunogenic peptide sequences from human or mouse SLFN5. Validated applications include Western blotting, immunofluorescence, and immunoprecipitation. Researchers rely on SLFN5 antibodies to explore its dual roles: as a tumor suppressor via epigenetic silencing of oncogenes or as a pro-tumor factor by dampening antitumor immunity. Challenges include distinguishing SLFN5 from other Schlafen family members (e.g., SLFN11) due to sequence homology, necessitating rigorous specificity validation. Recent studies also investigate SLFN5 phosphorylation and its impact on protein function, further driving demand for high-quality antibodies.