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DIMT1抗体

Rabbit Polyclonal DIMT1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-14

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
DIMT1抗体
英文名称：
Rabbit Polyclonal DIMT1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4981 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
DIMT1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesDIM1; DIMT1L; HUSSY5; HSA9761
WB Predicted band size35 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 231 and Raji cell lysates, Primary antibody: P09656(DIMT1 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09656(DIMT1 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09656(DIMT1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于DIMT1抗体的3篇示例参考文献(内容为虚构示例，仅供参考)：

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1. **文献名称**: *DIMT1 regulates mitochondrial apoptosis in cancer cells via rRNA modification*

**作者**: Zhang Y, et al.

**摘要**: 本研究利用DIMT1特异性抗体，通过Western blot和免疫组化技术，揭示了DIMT1通过调控18S rRNA的甲基化修饰影响线粒体凋亡通路，抑制DIMT1表达可增强化疗药物诱导的肿瘤细胞死亡。

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2. **文献名称**: *Developmental role of DIMT1 in mouse embryogenesis*

**作者**: Chen L, et al.

**摘要**: 通过DIMT1抗体进行组织特异性定位分析，发现DIMT1在小鼠胚胎早期发育中高表达，敲除后导致心脏和神经系统发育异常，提示其参与核糖体生物合成及细胞增殖调控。

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3. **文献名称**: *DIMT1 interacts with p53 to modulate oxidative stress response*

**作者**: Lee S, et al.

**摘要**: 使用DIMT1抗体进行免疫共沉淀实验，证实DIMT1与p53蛋白直接结合，协同调控下游抗氧化基因表达，缺失DIMT1的细胞对氧化应激敏感性显著升高。

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注：以上文献为示例，实际研究中请通过PubMed或Google Scholar以关键词“DIMT1 antibody”或“DIMT1 function”检索真实发表的论文。

       

背景信息

The DIMT1 (Disturbance of Meiotic Telomeres 1) antibody is a research tool used to detect and study the DIMT1 protein, a conserved eukaryotic protein implicated in ribosome biogenesis and cellular stress responses. DIMT1. originally identified in yeast (as Rlp24) and later in mammals, plays a critical role in the maturation of the large ribosomal subunit by facilitating the assembly of rRNA and ribosomal proteins. It is localized to the nucleolus and participates in the pseudouridylation of rRNA, a modification essential for ribosome stability and function.

Studies suggest DIMT1 is involved in regulating cell proliferation, differentiation, and apoptosis. Its dysregulation has been linked to cancer progression, neurodegenerative diseases, and developmental disorders. For instance, elevated DIMT1 expression has been observed in certain cancers, correlating with poor prognosis. In neuroscience, DIMT1 interacts with stress granule components, indicating a role in cellular adaptation to stress.

The DIMT1 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to analyze protein expression, subcellular localization, and interactions. It aids in elucidating DIMT1's molecular mechanisms in ribosome biogenesis, stress signaling, and disease pathways. Ongoing research continues to explore its potential as a therapeutic target or biomarker, emphasizing its importance in both basic and translational biomedical studies.

       
DIMT1抗体;DIMT1;DIMT1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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