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DHRS1抗体

Rabbit Polyclonal DHRS1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-14

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
DHRS1抗体
英文名称：
Rabbit Polyclonal DHRS1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4980 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
DHRS1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesSDR19C1
WB Predicted band size34 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human DHRS1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue lysate, Primary antibody: P09655(DHRS1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09655(DHRS1 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09655(DHRS1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于DHRS1抗体的3篇文献摘要信息，供参考：

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1. **文献名称**: *DHRS1 acts as a tumor suppressor in hepatocellular carcinoma via regulating retinoic acid signaling*

**作者**: Zhang Y, et al.

**摘要**: 本研究通过免疫组化(使用DHRS1特异性抗体)发现，DHRS1在肝癌组织中表达显著下调，并与患者不良预后相关。实验表明，DHRS1通过调控视黄酸代谢抑制肿瘤增殖，其抗体用于验证临床样本及细胞系中的蛋白表达水平。

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2. **文献名称**: *Dehydrogenase/reductase SDR family member 1 (DHRS1) modulates stem cell differentiation in colorectal cancer*

**作者**: Li H, et al.

**摘要**: 研究利用DHRS1抗体进行Western blot和免疫荧光分析，揭示DHRS1在结直肠癌干细胞中低表达，其缺失促进干细胞自我更新。抗体证实DHRS1过表达可抑制Wnt/β-catenin通路活性，提示其作为分化治疗靶点。

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3. **文献名称**: *DHRS1 is a novel regulator of cellular redox balance in breast cancer cells*

**作者**: Wang X, et al.

**摘要**: 本文开发了一种兔源多克隆DHRS1抗体，验证其在乳腺癌细胞中的特异性。研究发现DHRS1通过调节NAD+/NADH比例影响氧化应激反应，抗体数据支持其在维持细胞氧化稳态中的关键作用。

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**备注**：以上文献信息为示例性质，实际文献可能需要通过PubMed或Google Scholar以“DHRS1 antibody”为关键词检索确认。部分研究可能结合抗体应用探讨DHRS1的生物学功能及疾病机制。

       

背景信息

The DHRS1 (short-chain dehydrogenase/reductase family member 1) antibody is a tool used to detect and study the DHRS1 protein, a member of the short-chain dehydrogenase/reductase (SDR) superfamily. DHRS1 is an NAD+/NADP+-dependent enzyme implicated in redox reactions, though its precise physiological substrates and functions remain under investigation. It shares structural features with other SDR enzymes, including a conserved cofactor-binding domain and a catalytic triad, but exhibits unique tissue-specific expression patterns, with higher levels observed in the liver, kidney, and gastrointestinal tract.

Research suggests DHRS1 may play roles in cellular differentiation, apoptosis, and metabolic regulation. Its dysregulation has been linked to diseases such as cancer, where it may act as a tumor suppressor or promoter depending on context. For example, reduced DHRS1 expression correlates with poor prognosis in hepatocellular carcinoma, while overexpression is associated with gastric cancer progression.

DHRS1 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression, localization, and interactions in both normal and pathological tissues. These antibodies aid in elucidating DHRS1's role in disease mechanisms and potential therapeutic targeting. Commercial antibodies are typically validated for specificity using knockout controls or siRNA-mediated knockdown. Ongoing studies aim to clarify DHRS1's enzymatic activity, regulatory pathways, and clinical relevance across different biological contexts.

       
DHRS1抗体;DHRS1;DHRS1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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