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UBXN1抗体

Rabbit Polyclonal UBXN1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-14

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
UBXN1抗体
英文名称：
Rabbit Polyclonal UBXN1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4979 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
UBXN1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/40-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

Aliases2B28; SAKS1; UBXD10
WB Predicted band size33 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse brain tissue, Hela and HEPG2 cell lysates, Primary antibody: P09654(UBXN1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09654(UBXN1 Antibody) at dilution 1/35. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09654(UBXN1 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

参考文献

以下是关于UBXN1抗体的3篇参考文献示例(注：文献信息为虚构示例，仅用于格式演示，实际文献需通过数据库检索获取)：

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1. **标题**: "UBXN1 interacts with the NLRP3 inflammasome to regulate inflammatory responses"

**作者**: Smith A, et al.

**摘要**: 本研究利用UBXN1特异性抗体，通过免疫共沉淀和Western blot技术，揭示了UBXN1通过结合NLRP3炎症小体复合物抑制其活化，调控IL-1β的成熟与释放。

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2. **标题**: "UBXN1 is a critical mediator of p97/VCP-dependent protein degradation pathways"

**作者**: Chen L, et al.

**摘要**: 通过UBXN1抗体的免疫荧光和蛋白质互作分析，本文发现UBXN1作为p97/VCP的共调控因子，参与内质网相关降解(ERAD)途径，并影响错误折叠蛋白的清除效率。

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3. **标题**: "UBXN1 antibody-based profiling identifies its tumor-suppressive role in colorectal cancer"

**作者**: Wang Y, et al.

**摘要**: 研究采用UBXN1抗体进行组织芯片免疫组化分析，证实UBXN1在结直肠癌中低表达，其缺失与患者预后不良相关，机制涉及对Wnt/β-catenin通路的抑制作用。

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实际检索建议：

- 使用PubMed或Google Scholar搜索关键词“UBXN1 antibody”、“UBXN1 function”或“UBXN1 protein interaction”，筛选涉及抗体应用的文献。

- 关注UBXN1在细胞凋亡、蛋白降解或癌症中的研究，通常会在方法部分提及抗体使用。

       

背景信息

UBXN1 (UBX domain protein 1), also known as UBXD1. is a member of the UBX domain-containing protein family, characterized by a conserved ubiquitin regulatory X (UBX) domain that facilitates interactions with proteins involved in ubiquitin-dependent processes. It functions as a cofactor for p97/VCP (valosin-containing protein), a critical ATPase responsible for coordinating protein homeostasis, including endoplasmic reticulum-associated degradation (ERAD), autophagy, and DNA repair. UBXN1 is thought to regulate p97’s activity by modulating its ATPase cycle or substrate recruitment, thereby influencing proteasomal degradation pathways. Its role in ERAD involves recognizing and processing misfolded proteins tagged with ubiquitin for destruction, linking it to cellular stress responses and quality control mechanisms.

Antibodies targeting UBXN1 are essential tools for studying its expression, localization, and interactions in various biological contexts. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate UBXN1’s involvement in diseases such as cancer, neurodegenerative disorders, and myopathies, where p97-related pathways are dysregulated. Validation of UBXN1 antibodies often includes testing in knockout cell lines or tissues to confirm specificity. Research utilizing these antibodies has highlighted UBXN1’s regulatory roles in apoptosis, cell cycle progression, and viral infection responses, underscoring its broader significance in maintaining proteostatic balance and cellular health.

       
UBXN1抗体;UBXN1;UBXN1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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