GK5抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human breast cancer tissue lysate, Primary antibody: P09648(GK5 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09648(GK5 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The GK5 antibody targets the G protein-coupled receptor kinase 5 (GRK5), a serine/threonine kinase involved in regulating G protein-coupled receptor (GPCR) signaling. GRK5 phosphorylates activated GPCRs, promoting receptor desensitization and internalization, thus modulating cellular responses to hormones, neurotransmitters, and external stimuli. It plays critical roles in cardiovascular function, cell proliferation, and immune regulation. Dysregulation of GRK5 is linked to pathologies such as heart failure, cancer, and inflammatory diseases.

The GK5 antibody is widely used in research to study GRK5 expression, localization, and function in tissues and cell lines. It enables detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies utilizing this antibody have revealed GRK5's dual role in disease: while its overexpression in heart tissue exacerbates hypertrophy, its downregulation in certain cancers correlates with tumor progression.

Recent research highlights GRK5's potential as a therapeutic target, particularly in heart disease and oncology. The GK5 antibody serves as a key tool for validating experimental models, screening drug candidates, and elucidating GRK5-dependent signaling pathways. Its specificity and reliability make it essential for advancing understanding of GPCR-related mechanisms and developing targeted therapies.