FAM3B抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08309(FAM3B Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08309(FAM3B Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

FAM3B (Family with sequence similarity 3 member B) is a gene encoding a cytokine-like protein named PANcreatic DERived factor (PANDER). Predominantly expressed in pancreatic β-cells, FAM3B/PANDER plays a role in glucose metabolism regulation and β-cell dysfunction. Structurally, it contains 224 amino acids with conserved cysteine residues forming disulfide bonds, resembling cytokine signaling motifs. Studies suggest FAM3B participates in apoptosis induction, insulin secretion modulation, and interactions with metabolic pathways like PI3K/AKT and AMPK. However, its precise mechanisms remain debated, with conflicting evidence on pro-apoptotic versus β-cell protective roles.

FAM3B antibodies are essential tools for detecting protein expression, localization, and functional studies. They are widely used in Western blotting, immunohistochemistry, and immunofluorescence to investigate FAM3B's involvement in diabetes, pancreatic disorders, and cancers. Some studies link FAM3B overexpression to tumor progression in hepatocellular carcinoma and colorectal cancer. Commercial antibodies target specific epitopes (e.g., C-terminal regions) and are available as monoclonal or polyclonal variants. Validation in knockout models is critical due to potential cross-reactivity with FAM3 family paralogs. Research utilizing these antibodies continues to explore FAM3B's dual roles in metabolism and disease, highlighting its therapeutic and diagnostic potential.