EPDR1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue, human fetal muscle tissue, Primary antibody: P08287(EPDR1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08287(EPDR1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P08287(EPDR1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

EPDR1 (Ependymin-Related Protein 1) is a member of the ependymin family, a group of secreted glycoproteins originally identified in teleost fish and implicated in neural plasticity and regeneration. In humans, EPDR1 shares structural homology with ependymins, featuring a conserved MARVEL domain involved in membrane-associated processes. While its exact physiological role remains under investigation, EPDR1 is suggested to participate in cell adhesion, migration, and signaling pathways, with emerging links to cancer progression, lipid metabolism, and neurodegenerative disorders.

EPDR1 antibodies are immunological tools designed to detect and study the expression, localization, and function of the EPDR1 protein in research settings. These antibodies enable techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the exploration of EPDR1's tissue distribution (notably in brain, kidney, and adipose tissues) and its dysregulation in diseases. For instance, elevated EPDR1 levels have been observed in certain cancers, suggesting potential roles in tumor metastasis or therapy resistance.

Commercial EPDR1 antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein fragments. Validation data, including specificity checks via knockout controls and application-specific testing, are critical due to occasional cross-reactivity concerns. Ongoing research aims to clarify EPDR1's molecular mechanisms and therapeutic relevance, positioning EPDR1 antibodies as essential reagents for both basic and translational studies.