ENTPD5抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: P08286(ENTPD5 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08286(ENTPD5 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08286(ENTPD5 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

**Background of ENTPD5 Antibody**

The ENTPD5 (Ectonucleoside Triphosphate Diphosphohydrolase 5) antibody is a tool designed to detect and study the ENTPD5 protein, a member of the ectonucleoside triphosphate diphosphohydrolase family. ENTPD5. also known as CD39L4 or ER-UDPase, is an endoplasmic reticulum (ER)-localized enzyme that hydrolyzes nucleoside triphosphates and diphosphates, playing a role in regulating nucleotide homeostasis and protein glycosylation. It is implicated in modulating the unfolded protein response (UPR) by influencing the availability of UDP, a critical substrate for ER protein folding.

ENTPD5 is of interest in cancer research due to its overexpression in certain tumors, where it supports cell survival under stress conditions by promoting ER function and mitigating proteotoxic stress. Its role in tumor progression, metastasis, and drug resistance has made it a potential therapeutic target or biomarker.

The ENTPD5 antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression, localization, and interactions. Researchers utilize it to explore ENTPD5’s involvement in cellular stress responses, cancer biology, and metabolic regulation. Validation of antibody specificity, often through knockout controls or peptide blocking, ensures reliability in experimental models. This antibody continues to advance studies on ER dynamics, cancer mechanisms, and nucleotide signaling pathways.