KIAA1324抗体

The KIAA1324 antibody is a research tool developed to study the protein encoded by the KIAA1324 gene, also known as EIG121 or C7orf43. This gene, located on chromosome 7. has gained attention for its potential roles in cellular metabolism, stress response, and disease pathogenesis. KIAA1324 is implicated in metabolic regulation, particularly in lipid and glucose homeostasis, with studies linking its expression to insulin sensitivity and mitochondrial function. Aberrant KIAA1324 expression has been observed in cancers, including breast and ovarian tumors, where it may influence cell proliferation and survival pathways. The antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect KIAA1324 protein levels, localization, and interactions in biological samples. Both polyclonal and monoclonal versions exist, typically raised in rabbits or mice using peptide antigens derived from conserved regions of the protein. Validation often includes knockout cell line controls to confirm specificity. Recent research highlights its utility in exploring metabolic disorders and cancer biology, with efforts to characterize post-translational modifications and tissue-specific isoforms. Commercial availability through biotech vendors supports its growing application in preclinical studies, though standardization of protocols remains an ongoing focus for reproducibility.