EHHADH抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: P08268(EHHADH Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08268(EHHADH Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08268(EHHADH Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The EHHADH (Enoyl-CoA Hydratase and 3-Hydroxyacyl CoA Dehydrogenase) antibody is a tool used to detect the EHHADH protein, a bifunctional enzyme involved in fatty acid metabolism. EHHADH, primarily localized in peroxisomes, plays a critical role in the β-oxidation pathway, breaking down long-chain fatty acids into acetyl-CoA for energy production. This enzyme is particularly important in tissues with high metabolic demands, such as the liver, kidney, and heart.

Research on EHHADH has linked it to various metabolic disorders, including peroxisomal biogenesis defects and Zellweger syndrome, where impaired β-oxidation leads to systemic dysfunction. The EHHADH antibody is widely utilized in studies exploring lipid metabolism dysregulation, mitochondrial/peroxisomal crosstalk, and its potential role in diseases like diabetes, obesity, and cancer.

As a reagent, the antibody aids in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and interactions. Recent studies also investigate EHHADH's involvement in oxidative stress responses and inflammation, broadening its relevance in metabolic and degenerative disease research. Validation of antibody specificity remains crucial, as cross-reactivity with similar enzymes (e.g., mitochondrial HADHA/HADHB) could confound results. Overall, the EHHADH antibody serves as a key molecular tool for dissecting fatty acid metabolism pathways and their pathological implications.