ECHS1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Human liver tissue, 293T cells, MCF7 cells, PC3 cells, HepG2 cells, human fetal liver tissue, hela cells, Primary antibody: P08261(ECHS1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08261(ECHS1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P08261(ECHS1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

**Background of ECHS1 Antibody**

ECHS1 (Enoyl-CoA Hydratase Short Chain 1) is a mitochondrial enzyme involved in fatty acid β-oxidation, catalyzing the hydration of 2-trans-enoyl-CoA to 3-hydroxyacyl-CoA. It plays a critical role in energy metabolism and is essential for breaking down short-chain fatty acids and branched-chain amino acids. Dysregulation of ECHS1 has been linked to metabolic disorders, neurodegenerative diseases, and cancer, highlighting its physiological importance.

The ECHS1 antibody is a targeted immunological tool designed to detect and quantify ECHS1 protein expression in various biological samples. It is commonly produced in hosts like rabbits or mice using immunogenic peptides derived from conserved regions of the human ECHS1 protein. Validated for applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry, this antibody aids in studying ECHS1’s expression patterns, subcellular localization, and interactions in health and disease.

Research utilizing ECHS1 antibodies has provided insights into its role in mitochondrial dysfunction, metabolic reprogramming in cancer, and rare inborn errors of metabolism caused by ECHS1 mutations. These studies underscore its potential as a biomarker or therapeutic target. Quality validation, including knockout controls and cross-reactivity checks, ensures specificity, making the ECHS1 antibody a reliable reagent in both basic research and clinical investigations.