CCAR1抗体

The CCAR1 (Cell Cycle and Apoptosis Regulatory Protein 1) antibody is a tool used to study the multifunctional protein CCAR1. which plays critical roles in transcriptional regulation, cell cycle progression, and apoptosis. Initially identified as a coactivator for nuclear receptors, CCAR1 interacts with diverse signaling pathways, including p53-mediated DNA damage responses and β-catenin-dependent transcription. It is implicated in maintaining genomic stability, coordinating cell division checkpoints, and modulating apoptotic signals. Dysregulation of CCAR1 has been linked to cancer progression, therapy resistance, and metastasis. Researchers employ CCAR1 antibodies in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to investigate its expression patterns, subcellular localization, and molecular interactions. Recent studies highlight its involvement in splicing regulation and epigenetic modifications, expanding its relevance in cellular stress responses and oncogenesis. The antibody’s specificity enables detection of CCAR1 isoforms and post-translational modifications, aiding mechanistic studies in cancer biology and targeted therapy development. Commercial antibodies are typically validated in knockout cell lines to ensure reliability in experimental models.