DIDO1抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08215(DIDO1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P08215(DIDO1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The Dido1 (Death Inducer-Obliterator 1) antibody targets the protein encoded by the DIDO1 gene, which plays multifaceted roles in cellular processes such as apoptosis, transcriptional regulation, and chromosome segregation. Initially identified as a pro-apoptotic factor, Dido1 contains conserved structural domains, including a SPOC (Spen Paralog and Ortholog C-terminal) domain, implicating its involvement in RNA splicing and epigenetic regulation. Studies highlight its critical function in maintaining embryonic stem cell pluripotency by interacting with core transcription factors like Oct4. and in regulating the cell cycle through associations with the chromosomal passenger complex during mitosis.

Dido1 antibodies are essential tools for investigating its expression, localization, and post-translational modifications across various isoforms (Dido1-3). These antibodies enable detection via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding research into its role in cancer, where DIDO1 dysregulation is linked to genomic instability and tumor progression. Additionally, Dido1's interaction with histone modifiers suggests a role in epigenetic regulation, potentially influencing differentiation and DNA damage responses. Its isoforms may serve as biomarkers in diseases, including leukemia and solid tumors. The antibody's specificity and applications vary depending on the targeted epitope, making it crucial for mechanistic studies in stem cell biology, oncology, and developmental processes.