CORO1C抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Lovo cells, Primary antibody: P08173(CORO1C Antibody) at dilution 1/530, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08173(CORO1C Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08173(CORO1C Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The CORO1C antibody targets coronin-1C (also known as Coronin-3 or CORO1C), a member of the coronin protein family involved in regulating cytoskeletal dynamics. Coronins are evolutionarily conserved actin-binding proteins that modulate actin polymerization, cell motility, vesicle trafficking, and immune responses. CORO1C is ubiquitously expressed and localizes to dynamic actin-rich structures, including lamellipodia, endosomes, and the Golgi apparatus. It interacts with the Arp2/3 complex and cofilin to fine-tune actin filament assembly and disassembly.

Research highlights its role in cell migration, intracellular trafficking, autophagy, and cytokinesis. Dysregulation of CORO1C has been linked to cancer progression, neurodegenerative diseases, and immune disorders. For instance, elevated CORO1C expression correlates with tumor metastasis in certain cancers, likely due to enhanced invasive cell behavior. Additionally, CORO1C mutations or altered expression may contribute to neurodevelopmental defects.

CORO1C antibodies are widely used in biomedical research to study its subcellular localization, protein-protein interactions, and functional mechanisms through techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. These tools help elucidate CORO1C's contribution to physiological and pathological processes, offering potential therapeutic insights.