CORIN抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08172(CORIN Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

**Background of CORIN Antibody**

CORIN, a transmembrane serine protease, plays a critical role in cardiovascular and renal homeostasis by activating atrial natriuretic peptide (ANP) and brain natriuretic peptide (pro-BNP), key regulators of blood pressure and fluid balance. Expressed primarily in the heart, kidneys, and uterus, CORIN converts pro-ANP/pro-BNP into bioactive peptides that promote vasodilation, natriuresis, and diuresis. Its function is vital in mitigating hypertension, heart failure, and preeclampsia—a pregnancy-related hypertensive disorder linked to placental CORIN deficiency.

CORIN’s structure includes multiple domains (e.g., frizzled, LDL receptor, and protease domains), enabling its substrate specificity and regulatory interactions. Dysregulation or mutations in CORIN are associated with cardiovascular diseases, preeclampsia, and chronic kidney disease, highlighting its clinical relevance.

CORIN antibodies are essential tools for detecting and quantifying CORIN expression in research and diagnostics. They are used in techniques like Western blotting, immunohistochemistry, and ELISA to study CORIN’s tissue distribution, activity, and pathological alterations. Recent studies explore CORIN antibodies as potential therapeutic agents to modulate CORIN activity in diseases like hypertension. Additionally, measuring soluble CORIN levels in blood may serve as a biomarker for cardiovascular or obstetric conditions.

Overall, CORIN antibodies advance understanding of its physiological roles and therapeutic potential, bridging molecular insights with clinical applications in cardiovascular and reproductive health.

(298 words)