CNTROB抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse kidney tissue, Primary antibody: P08167(CNTROB Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

The CNTROB (Centrobin) antibody is a research tool designed to target the Centrobin protein, a key centrosomal component involved in centriole duplication and cell cycle regulation. Encoded by the *CNTROB* gene in humans, Centrobin is predominantly localized to the daughter centriole, where it plays a critical role in maintaining centriole integrity and ensuring proper mitotic progression. Structurally, it contains coiled-coil domains that facilitate interactions with other centrosomal proteins like PCM1 and Pericentrin, contributing to centrosome maturation and microtubule organization.

CNTROB's function extends beyond structural support; it regulates the G1/S transition by influencing cyclin E/CDK2 activity, linking centrosome dynamics to cell cycle control. Dysregulation of CNTROB has been implicated in cancers, including breast and prostate cancer, where its overexpression correlates with tumor aggressiveness and genomic instability. Additionally, mutations or altered expression may contribute to neurodevelopmental disorders due to disrupted neuronal cell division.

The CNTROB antibody is widely used in techniques like immunofluorescence, Western blotting, and immunoprecipitation to study centrosome biology, centriole duplication mechanisms, and disease-associated anomalies. Its specificity enables researchers to visualize subcellular localization, assess protein expression levels, and explore interactions within the centrosomal network. As a vital reagent in cell biology and oncology research, this antibody aids in elucidating how centrosomal aberrations drive pathological processes, offering potential insights for therapeutic targeting.