CLIP1抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08164(CLIP1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The CLIP1 (CAP-Gly Domain Containing Linker Protein 1) antibody is a tool used to study the function and localization of the CLIP1 protein, a key regulator of microtubule dynamics in eukaryotic cells. CLIP1. also known as CLIP-170. belongs to the family of cytoplasmic linker proteins (CLIPs) that mediate interactions between microtubules and intracellular organelles or signaling molecules. It contains an N-terminal CAP-Gly domain, which enables binding to microtubule plus ends, and coiled-coil regions facilitating dimerization and interactions with other proteins like dynein/dynactin complexes.

CLIP1 plays critical roles in vesicular transport, cell polarity, mitosis, and cytoskeletal organization by promoting microtubule stabilization and guiding directional cargo movement. Its dysfunction has been linked to neurological disorders, cancer metastasis, and impaired immune cell trafficking. The CLIP1 antibody is widely used in techniques such as immunofluorescence, Western blotting, and immunoprecipitation to detect CLIP1 expression levels, subcellular distribution, and protein-protein interactions. Researchers employ it to investigate mechanisms underlying microtubule-dependent processes, disease pathologies, or drug effects on cytoskeletal dynamics. Commercial CLIP1 antibodies are typically raised against specific epitopes (e.g., human CLIP1 N-terminal regions) and validated for cross-reactivity in various model organisms, ensuring versatility in both basic and translational studies.