CENPH抗体

The CENPH antibody is a crucial tool in studying the molecular mechanisms of chromosome segregation during cell division. CENPH (Centromere Protein H) is a core component of the constitutive centromere-associated network (CCAN), a protein complex essential for kinetochore assembly and proper attachment of spindle microtubules during mitosis and meiosis. It plays a pivotal role in maintaining centromere integrity, ensuring accurate chromosomal segregation, and preventing aneuploidy—a hallmark of many cancers and genetic disorders. Researchers use CENPH antibodies primarily in immunofluorescence, Western blotting, and immunoprecipitation to investigate centromere dynamics, cell cycle regulation, and chromosomal instability. These antibodies help visualize CENPH localization at centromeres, assess its expression levels across cell cycle stages, and explore interactions with other centromeric proteins like CENP-A and CENP-C. Dysregulation of CENPH has been implicated in cancers, including hepatocellular carcinoma and colorectal cancer, making its study relevant for understanding tumorigenesis. Available as monoclonal or polyclonal variants, CENPH antibodies are validated for specificity across human and model organisms, aiding both basic research and clinical studies on chromosomal disorders and targeted therapies.