CATSPER1抗体

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P08109(CATSPER1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08109(CATSPER1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

The CATSPER1 antibody is a specialized tool used to detect and study the CATSPER1 protein, a key component of the CatSper (Cation Channel of Sperm) ion channel family. CatSper channels are sperm-specific, pH-sensitive calcium channels essential for sperm hyperactivation, motility, and fertilization. Among the four CatSper subunits (CatSper1-4), CATSPER1 forms the pore-forming subunit and is critical for channel assembly and function. Mutations in the CATSPER1 gene are linked to male infertility due to impaired sperm motility and failed egg penetration.

CATSPER1 antibodies are primarily employed in reproductive biology research to investigate sperm physiology, infertility mechanisms, and contraceptive development. These antibodies enable the localization and quantification of CATSPER1 in sperm cells using techniques like Western blotting, immunofluorescence, and flow cytometry. Their specificity helps differentiate CATSPER1 from other ion channels and assess its expression levels in pathological conditions.

Recent studies also explore CATSPER1's role beyond fertility, including potential signaling functions in cancer cells. However, challenges persist in antibody validation due to the channel's structural complexity and low abundance in sperm membranes. Despite this, CATSPER1 antibodies remain vital for understanding calcium signaling in sperm and developing targeted therapies for infertility or non-hormonal contraceptives.