CAPZA3抗体

The CAPZA3 antibody is designed to target the CAPZA3 protein, a member of the F-actin capping protein alpha subunit family. CAPZA3. specifically expressed in the testis and germ cells, plays a critical role in regulating actin cytoskeleton dynamics during spermatogenesis. Unlike its ubiquitously expressed homologs (CAPZA1 and CAPZA2), CAPZA3 exhibits tissue-specific expression, suggesting specialized functions in sperm development, particularly in acrosome formation and sperm head shaping. Studies indicate that CAPZA3 interacts with its beta subunit (CAPZB) to stabilize actin filaments, ensuring structural integrity during spermiogenesis. Dysregulation of CAPZA3 has been linked to male infertility, as mutations or altered expression may disrupt sperm maturation or motility. The CAPZA3 antibody is widely used in reproductive biology research to investigate protein localization, expression levels, and molecular mechanisms underlying fertility issues. It enables techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the study of testicular pathologies or genetic models. Commercial antibodies are typically validated for specificity in human or mouse tissues, supporting both basic and clinical research focused on understanding cytoskeletal contributions to gametogenesis and reproductive health.