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CAPZA2抗体

Rabbit Polyclonal CAPZA2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-14

湖北瑞和宁生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
CAPZA2抗体
英文名称：
Rabbit Polyclonal CAPZA2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 3934 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
CAPZA2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesCAPZ; CAPPA2
WB Predicted band size33 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human CAPZA2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 15%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Lovo cells, hela cells, NIH/3T3 cells, mouse liver tissue, Mouse muscle tissue, Primary antibody: P08099(CAPZA2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08099(CAPZA2 Antibody) at dilution 1/15. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P08099(CAPZA2 Antibody) at dilution 1/15. (Original magnification: ×200)    


           

参考文献

以下是关于CAPZA2抗体的3篇参考文献及简要摘要：

1. **标题**：*CAPZA2 modulates cell migration and invasion in breast cancer via actin cytoskeleton dynamics*

**作者**：Li X, et al.

**摘要**：该研究通过免疫荧光和Western blot分析CAPZA2在乳腺癌中的表达，发现其通过调节F-actin组装影响细胞迁移和侵袭能力，提示其作为转移抑制因子的潜在作用。

2. **标题**：*CAPZA2 interacts with neurodevelopmental proteins and regulates dendritic spine formation*

**作者**：Wang Y, et al.

**摘要**：利用CAPZA2特异性抗体进行共免疫沉淀和质谱分析，揭示了CAPZA2与突触相关蛋白的相互作用，表明其在神经元树突棘形态发生中的关键调控功能。

3. **标题**：*Proteomic analysis of CAPZA2-deficient cells reveals its role in autophagosome-lysosome fusion*

**作者**：Chen H, et al.

**摘要**：通过敲低CAPZA2并结合免疫印迹和免疫电镜技术，发现其缺失导致自噬体-溶酶体融合障碍，提示CAPZA2通过稳定微丝网络参与自噬调控。

注：以上文献为示例，实际引用需核对PubMed/Google Scholar等数据库获取真实论文信息。

       

背景信息

The CAPZA2 antibody targets the alpha-2 subunit of the F-actin capping protein (CapZ), a conserved heterodimer (α/β) crucial for regulating actin filament dynamics. CapZ binds to the fast-growing (barbed) ends of actin filaments, stabilizing them by preventing uncontrolled polymerization or depolymerization. This regulation is vital for processes like cell motility, morphogenesis, and endocytosis. The CAPZA2 subunit, encoded by the CAPZA2 gene, is ubiquitously expressed and interacts with membrane-associated proteins, signaling molecules, and other cytoskeletal regulators (e.g., ARP2/3 complex, cofilin) to coordinate actin remodeling.

Antibodies against CAPZA2 are widely used in research to study its localization, expression levels, and functional roles in cellular processes. Dysregulation of CAPZA2 has been linked to pathologies, including cancer metastasis (e.g., breast, prostate) and neurological disorders, where aberrant actin dynamics contribute to disease progression. Commercial CAPZA2 antibodies are typically validated for techniques like Western blotting, immunofluorescence, and immunohistochemistry. Recent studies also explore its involvement in immune cell function and synaptic plasticity, highlighting its broad relevance. However, specificity validation (e.g., knockout controls) remains essential due to potential cross-reactivity with other CapZ isoforms.

       
CAPZA2抗体;CAPZA2;CAPZA2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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