CACNB1抗体

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P08089(CACNB1 Antibody) at dilution 1/100. (Original magnification: ×200)    

  
  

**Background of CACNB1 Antibody**

The CACNB1 antibody is a research tool targeting the β1 subunit of voltage-gated calcium channels (VGCCs), encoded by the *CACNB1* gene. VGCCs regulate calcium influx in excitable cells, influencing processes like muscle contraction, neurotransmitter release, and gene expression. The β1 subunit, part of the auxiliary β-subunit family (β1-β4), modulates channel trafficking, gating, and kinetics, particularly in L-type calcium channels (e.g., Cav1.2).

CACNB1 antibodies are widely used to study protein expression, localization, and function in tissues such as the heart, brain, and smooth muscle. They aid in investigating calcium channel dysfunction linked to cardiovascular diseases (e.g., arrhythmias, hypertension), neurological disorders (e.g., epilepsy, migraines), and cancers. Mutations in *CACNB1* are associated with conditions like Brugada syndrome and Timothy syndrome, making these antibodies critical for mechanistic and diagnostic research.

In experimental applications, CACNB1 antibodies are employed in Western blotting, immunohistochemistry, and immunofluorescence. Their specificity is validated using knockout controls or peptide-blocking assays. Commercial variants may differ in clonality (monoclonal/polyclonal), species reactivity, or epitope targets. As calcium signaling is a therapeutic focus, CACNB1 antibodies also support drug discovery by identifying modulators of channel activity.