BMP15抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: P08077(BMP15 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08077(BMP15 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P08077(BMP15 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

BMP15 (Bone Morphogenetic Protein 15), a member of the transforming growth factor-β (TGF-β) superfamily, is a critical oocyte-secreted factor regulating folliculogenesis and female fertility. Primarily expressed in oocytes, BMP15 interacts with granulosa cells to modulate follicular development, ovulation, and luteinization. It functions synergistically with GDF9 (Growth Differentiation Factor 9) to promote early follicle growth, inhibit premature luteinization, and maintain oocyte quality. Dysregulation of BMP15 is linked to reproductive disorders such as premature ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS).

BMP15 antibodies are essential tools for studying its expression, localization, and function in reproductive tissues. These antibodies enable detection of BMP15 in immunoassays (e.g., Western blot, immunohistochemistry) and facilitate research into its signaling pathways, including interactions with receptors (e.g., BMPR2. ACVR1B) and downstream SMAD proteins. Clinically, BMP15 antibodies may aid in diagnosing fertility-related conditions or developing therapeutic strategies, such as ovarian stimulation protocols. Challenges include ensuring antibody specificity due to structural similarities among TGF-β family members. Recent studies also explore BMP15's role in non-reproductive systems, expanding its potential biomedical relevance.