BIN3抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 231 cells, LoVo cells, HepG2 cells, Primary antibody: P08071(BIN3 Antibody) at dilution 1/275, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

The BIN3 (Bridging Integrator 3) antibody is a tool used to study the BIN3 protein, a member of the BAR (Bin/Amphiphysin/Rvs) domain-containing protein family. BIN3 is implicated in membrane dynamics, cytoskeletal organization, and intracellular trafficking. It interacts with phospholipids and other proteins to regulate membrane curvature, vesicle formation, and receptor endocytosis, influencing processes like cell migration, polarity, and signaling. BIN3 is also linked to pathways such as Hippo, which controls organ size and tumor suppression, and may interact with actin-modulating proteins.

Research associates BIN3 with cancer progression, neurological disorders, and immune regulation, though its exact mechanisms remain under investigation. The BIN3 antibody enables detection and localization of BIN3 in cells or tissues via techniques like Western blotting, immunofluorescence, or immunohistochemistry. It helps explore BIN3’s expression patterns, post-translational modifications, and interactions in normal or diseased states. Commercial BIN3 antibodies are typically raised against specific epitopes (e.g., human BIN3 N-terminal regions) and validated for specificity. Studying BIN3 may reveal insights into membrane-cytoskeleton interplay and its role in pathologies, potentially aiding therapeutic target discovery.