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COPB1抗体

Rabbit Polyclonal COPB1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-14

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
COPB1抗体
英文名称：
Rabbit Polyclonal COPB1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 3917 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
COPB1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesCOPB
WB Predicted band size107 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human COPB1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Raji cells, Primary antibody: P08068(COPB1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08068(COPB1 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P08068(COPB1 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于COPB1抗体的参考文献示例(注：部分内容基于真实研究背景，但文献名称和作者为虚构示例，建议通过学术数据库核实具体信息)：

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1. **文献名称**: "COPB1 as a Novel Prognostic Biomarker in Hepatocellular Carcinoma: Insights from Antibody-Based Detection"

**作者**: Zhang et al.

**摘要**: 研究通过COPB1抗体检测发现，COPB1在肝细胞癌(HCC)组织中显著过表达，与患者生存率负相关，提示其作为潜在预后标志物和治疗靶点的可能性。

2. **文献名称**: "COPB1 Antibody-Mediated Inhibition Suppresses HPV-Positive Cervical Cancer Progression"

**作者**: Wang et al.

**摘要**: 研究发现COPB1与HPV E6/E7蛋白相互作用，促进宫颈癌细胞增殖。使用COPB1抗体阻断其功能可显著抑制肿瘤生长，为靶向治疗提供依据。

3. **文献名称**: "COPB1 Regulates EGFR Trafficking in Glioblastoma: Mechanistic Studies Using Knockdown and Antibody Approaches"

**作者**: Smith et al.

**摘要**: 通过COPB1抗体和基因沉默技术，揭示COPB1通过调控EGFR膜转运影响胶质母细胞瘤的侵袭性，为靶向囊泡运输的抗癌策略奠定基础。

4. **文献名称**: "COPB1 Antibody Interferes with SARS-CoV-2 Virion Assembly by Disrupting Golgi-ER Retrograde Transport"

**作者**: Li et al.

**摘要**: 研究显示，COPB1抗体可阻断宿主细胞高尔基体-内质网运输，抑制SARS-CoV-2病毒颗粒组装，提出COPB1作为抗病毒治疗新靶点。

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建议通过PubMed或Google Scholar以关键词“COPB1 antibody”、“COPB1 biomarker”或“COPB1 viral infection”检索最新文献获取准确信息。

       

背景信息

**Background of COPB1 Antibody**

COPB1 (Coatomer Protein Complex Subunit Beta 1) is a key component of the COPI (coatomer protein complex I) vesicle transport system, which mediates retrograde trafficking of proteins and lipids between the Golgi apparatus and the endoplasmic reticulum. This process is critical for maintaining organelle structure, protein sorting, and cellular homeostasis. COPB1. specifically, plays a role in COPI coat assembly and cargo selection, ensuring proper vesicle formation and intracellular trafficking.

Antibodies targeting COPB1 are widely used in research to study COPI-mediated transport mechanisms, vesicle dynamics, and Golgi-ER interactions. They enable the detection and localization of COPB1 in various experimental models (e.g., Western blot, immunofluorescence, immunoprecipitation) to investigate its expression, interactions, and functional roles. Dysregulation of COPB1 has been implicated in diseases such as cancer, neurodegenerative disorders, and viral infections, where disrupted vesicular trafficking contributes to pathogenesis. For instance, altered COPB1 expression has been observed in certain tumors, linking it to cell proliferation and metastasis.

COPB1 antibodies are essential tools for elucidating COPI-related pathways and validating cellular models with COPB1 knockdown or overexpression. Their specificity and reliability make them valuable in both basic research and translational studies exploring trafficking-related pathologies.

       
COPB1抗体;COPB1;COPB1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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