BAAT抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human normal liver tissue, Primary antibody: P08061(BAAT Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08061(BAAT Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08061(BAAT Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

BAAT (Bile Acid-CoA: Amino Acid N-Acyltransferase) is a critical enzyme in bile acid metabolism, responsible for catalyzing the conjugation of bile acids with amino acids (primarily glycine or taurine) in the liver. This process produces conjugated bile acids, which are essential for emulsifying dietary fats, facilitating lipid absorption, and regulating cholesterol homeostasis. Dysregulation of BAAT activity is linked to cholestatic liver diseases, metabolic disorders, and rare genetic conditions like familial hypercholanemia.

BAAT antibodies are immunological tools developed to detect, quantify, and study the expression, localization, and function of the BAAT protein in research and clinical contexts. They are widely used in techniques such as Western blotting, immunohistochemistry, and ELISA to investigate BAAT’s role in liver pathophysiology, drug-induced hepatotoxicity, and bile acid synthesis disorders. Polyclonal and monoclonal BAAT antibodies enable researchers to explore tissue-specific expression patterns, protein-protein interactions, and mutations affecting enzyme activity.

Recent studies also utilize BAAT antibodies to validate gene-editing outcomes (e.g., CRISPR/Cas9) and assess therapeutic interventions targeting bile acid metabolism. Their application extends to diagnostic research for conditions like progressive familial intrahepatic cholestasis (PFIC), where BAAT mutations may contribute to disease progression. Overall, BAAT antibodies serve as pivotal reagents in advancing our understanding of hepatic function and metabolic diseases.