ATP6AP2抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08057(ATP6AP2 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

**Background of ATP6AP2 Antibody**

ATP6AP2 (ATPase H+ Transporting Accessory Protein 2), also known as (pro)renin receptor [(P)RR], is a multifunctional transmembrane protein involved in diverse cellular processes. It serves as an accessory subunit of the vacuolar H+-ATPase (V-ATPase) complex, essential for acidifying intracellular compartments like endosomes and lysosomes, thereby regulating processes such as protein degradation, autophagy, and vesicle trafficking. Additionally, ATP6AP2 acts as a receptor for prorenin and renin, linking it to the renin-angiotensin system (RAS), which modulates blood pressure and fluid homeostasis.

Antibodies targeting ATP6AP2 are critical tools in studying its expression, localization, and functional roles. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect ATP6AP2 in tissues or cultured cells. These antibodies help elucidate its involvement in physiological and pathological contexts, including neurodevelopment, immune regulation, and energy metabolism. Dysregulation of ATP6AP2 is implicated in diseases such as X-linked Parkinsonism, immunodeficiency, and diabetes, highlighting its therapeutic relevance.

Research using ATP6AP2 antibodies has also explored its role in viral entry (e.g., SARS-CoV-2) and cancer progression. However, challenges remain in distinguishing its full-length form from processed fragments, necessitating antibody validation for specificity. Overall, ATP6AP2 antibodies are indispensable for unraveling the protein’s dual roles in cellular physiology and disease mechanisms.