基本信息 产品详情 公司简介 推荐产品
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
网站主页 HTR3C抗体 HTR3C抗体
  • HTR3C抗体
  • HTR3C抗体
  • HTR3C抗体

1/3

HTR3C抗体

Rabbit Polyclonal HTR3C Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-14

湖北瑞和宁生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
HTR3C抗体
英文名称：
Rabbit Polyclonal HTR3C Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 3897 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
HTR3C

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

WB Predicted band size50 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human HTR3C
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human cerebrum tissue lysate, Primary antibody: P08036(HTR3C Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08036(HTR3C Antibody) at dilution 1/40. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08036(HTR3C Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于HTR3C抗体的参考文献示例(内容为模拟，建议通过学术数据库验证)：

---

1. **文献名称**：*"Characterization of a polyclonal antibody against the human 5-HT3C receptor subunit"*

**作者**：Thompson AJ, et al.

**摘要**：本研究开发了一种针对HTR3C亚基的多克隆抗体，验证了其在HEK293细胞和人体组织中的特异性。结果表明，HTR3C与HTR3A共表达于肠道神经元，可能参与内脏痛觉信号传导。

2. **文献名称**：*"Differential expression of 5-HT3 receptor subtypes in colorectal cancer and its clinical implications"*

**作者**：Smith LM, et al.

**摘要**：通过HTR3C特异性抗体检测发现，HTR3C在结直肠癌细胞中高表达，与化疗耐药性相关。研究提示HTR3C可能成为癌症治疗的潜在靶点。

3. **文献名称**：*"Development of selective monoclonal antibodies for 5-HT3 receptor subunits and their application in neuropsychiatric disorders"*

**作者**：Brown KA, et al.

**摘要**：报道了一种高特异性HTR3C单克隆抗体的开发，并用于分析精神分裂症患者脑组织中HTR3C的表达变化，发现其与认知功能障碍存在关联。

4. **文献名称**：*"Functional analysis of HTR3C variants using antibody-based protein quantification in migraine patients"*

**作者**：Zhang R, et al.

**摘要**：利用抗HTR3C抗体检测偏头痛患者中受体表达水平，发现特定基因突变导致HTR3C蛋白稳定性下降，可能影响5-HT3受体复合物的功能。

---

**注意**：以上为模拟示例，实际文献请通过PubMed、Google Scholar等平台检索关键词(如“HTR3C antibody”、“5-HT3C receptor”)获取。

       

背景信息

The HTR3C antibody is a research tool designed to detect and study the 5-hydroxytryptamine receptor 3C (HTR3C), a subunit of the serotonin-gated ion channel receptor family (5-HT3). The 5-HT3 receptor is unique among serotonin receptors as a ligand-gated cation channel, primarily involved in fast synaptic neurotransmission. It plays critical roles in regulating nausea, vomiting, pain perception, and gastrointestinal functions. HTR3C combines with other subunits (e.g., HTR3A or HTR3B) to form functional heteropentameric receptors, though its exact physiological contributions remain less characterized compared to the more widely expressed HTR3A subunit.

Antibodies targeting HTR3C are typically developed against specific epitopes, such as extracellular N-terminal domains or intracellular loops, to enable applications like Western blotting, immunohistochemistry, or immunofluorescence. These tools help map HTR3C expression patterns in tissues like the enteric nervous system, where it may influence gut motility, or in brain regions linked to psychiatric disorders. Research using HTR3C antibodies has explored its potential associations with conditions such as irritable bowel syndrome (IBS), chemotherapy-induced emesis, and neuropsychiatric diseases. However, challenges persist in ensuring antibody specificity due to structural similarities among 5-HT3 receptor subunits. Validation via knockout controls or siRNA knockdown is often recommended to confirm target selectivity, particularly in studies involving heteromeric receptor complexes.

       
HTR3C抗体;HTR3C;HTR3C Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

HTR3C抗体相关厂家报价

  • 抗CRF抗体
  • 抗CRF抗体
  • 维百奥（北京）生物科技有限公司 VIP
  • 2025-12-29
  • 询价
内容声明
official 进入官方账号
拨打电话 立即询价