ASNS抗体

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     Gel: 15%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Lovo cells, 231 cells, Primary antibody: P08035(ASNS Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08035(ASNS Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

**Background of ASNS Antibodies**

ASNS (Asparagine Synthetase) antibodies are autoantibodies targeting the enzyme asparagine synthetase, which catalyzes the conversion of aspartate and glutamine to asparagine and glutamate. This enzyme plays a critical role in amino acid metabolism, supporting cellular functions such as protein synthesis and nitrogen balance. ASNS is expressed in various tissues, including the liver, brain, and pancreas, and its activity is particularly important in cancer cells, which often rely on exogenous asparagine uptake for survival.

ASNS antibodies have been studied in the context of autoimmune and neurological disorders. For instance, they are occasionally detected in autoimmune hepatitis, though their clinical significance remains unclear. Recent research highlights their potential association with neuropsychiatric conditions, such as autoimmune encephalitis, where immune dysregulation targets brain-specific proteins. The presence of ASNS antibodies may indicate an aberrant immune response, possibly triggered by molecular mimicry or epitope spreading.

In diagnostics, ASNS antibodies are identified using techniques like ELISA or immunoblotting. However, their role as biomarkers is not well-established, requiring further validation. Studies also explore ASNS inhibition in cancer therapy, as limiting asparagine availability may suppress tumor growth. Overall, while ASNS antibodies provide insights into autoimmune mechanisms and metabolic pathways, their pathophysiological relevance and therapeutic potential warrant deeper investigation.