ASCC1抗体

The ASCC1 (Activating Signal Cointegrator 1 Complex Subunit 1) antibody is a research tool used to study the ASCC1 protein, a component of the ASCC complex involved in transcriptional regulation and DNA repair. ASCC1 is part of a larger protein complex that interacts with transcription factors, such as ATF5. and plays a role in modulating gene expression in response to cellular stress. It also contributes to the resolution of RNA-DNA hybrids (R-loops) and maintains genome stability by participating in the alkylation damage repair pathway through its association with ALKBH3. a DNA/RNA demethylase. Dysregulation of ASCC1 has been linked to cancer progression and chemoresistance, as its loss can impair DNA repair mechanisms and sensitize cells to alkylating agents. Researchers employ ASCC1 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression levels, subcellular localization, and interactions in various biological contexts. These studies help elucidate ASCC1's role in transcriptional control, DNA damage response, and its potential as a therapeutic target in oncology or diseases associated with genomic instability.