ASAH2抗体

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Lovo cells, mouse heart tissue, Primary antibody: P08027(ASAH2 Antibody) at dilution 1/270, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P08027(ASAH2 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08027(ASAH2 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The ASAH2 antibody targets the enzyme N-acylsphingosine amidohydrolase 2 (ASAH2), a member of the acid ceramidase family. ASAH2 hydrolyzes ceramide into sphingosine and free fatty acids, playing a key role in sphingolipid metabolism. Unlike its isoform ASAH1. which is lysosomal and involved in hereditary disorders like Farber disease, ASAH2 is secreted or membrane-associated, influencing extracellular ceramide signaling. This enzyme is implicated in regulating cellular processes such as apoptosis, inflammation, and immune responses, with altered activity linked to cancer progression, neurodegenerative diseases, and metabolic syndromes.

ASAH2 antibodies are critical research tools for detecting protein expression, localization, and function in vitro and in vivo. Studies using these antibodies have revealed ASAH2's overexpression in certain cancers, where it may promote tumor survival by modulating ceramide levels. Additionally, ASAH2's role in lipid signaling pathways has spurred interest in its therapeutic potential, with antibodies aiding in drug development and mechanistic studies. Despite progress, the full scope of ASAH2's biological and pathological roles remains under investigation, highlighting the importance of high-specificity antibodies for advancing research into sphingolipid-related diseases and therapies.