NPPA抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08023(NPPA Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P08023(NPPA Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of NPPA Antibody**

The NPPA (Natriuretic Peptide Precursor A) gene encodes atrial natriuretic peptide (ANP), a hormone primarily secreted by cardiac atrial cells in response to mechanical stress, volume overload, or hypertension. ANP plays a critical role in regulating blood pressure, fluid balance, and cardiovascular homeostasis by promoting natriuresis, diuresis, and vasodilation. Dysregulation of ANP expression is associated with cardiovascular diseases, including heart failure, atrial fibrillation, and hypertension.

NPPA antibodies are essential tools for detecting and quantifying ANP in research and diagnostics. These antibodies target specific epitopes of the ANP precursor or mature peptide, enabling applications such as immunohistochemistry, Western blotting, ELISA, and immunofluorescence. They aid in studying ANP's physiological roles, its secretion dynamics, and its pathological alterations in disease models.

The development of high-specificity NPPA antibodies has advanced understanding of ANP's interaction with receptors (e.g., NPR-A) and its downstream signaling pathways. Cross-reactivity studies often confirm their applicability across species (e.g., human, mouse, rat), supporting translational research. Commercial NPPA antibodies are validated for precision, though variability in sensitivity or specificity between clones requires careful experimental optimization. Overall, NPPA antibodies remain pivotal in cardiovascular research, biomarker discovery, and therapeutic targeting.