CERK抗体

CERK (ceramide kinase) antibodies are essential tools in studying the role of ceramide kinase, an enzyme that phosphorylates ceramide to produce ceramide-1-phosphate (C1P). CERK is a key regulator of sphingolipid metabolism, influencing cellular processes like apoptosis, inflammation, and proliferation. C1P, its product, acts as a bioactive lipid involved in membrane dynamics, signaling pathways, and immune responses. Dysregulation of CERK activity or expression has been linked to diseases such as cancer, neurodegenerative disorders, and inflammatory conditions. Antibodies targeting CERK enable researchers to detect and quantify its expression in tissues or cells, assess its subcellular localization, and investigate its interaction partners. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies utilizing CERK antibodies have explored its role in modulating macrophage activation, cancer cell survival, and neuronal health. However, challenges remain in understanding tissue-specific CERK functions and its crosstalk with other lipid mediators. Developing highly specific CERK antibodies continues to advance research into sphingolipid-related pathologies and potential therapeutic targets.