CSNK1E抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08015(CSNK1E Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The casein kinase 1 epsilon (CSNK1E) antibody is a key tool for studying the CSNK1E protein, a member of the casein kinase 1 (CK1) serine/threonine kinase family. CSNK1E plays diverse roles in cellular processes, including Wnt/β-catenin signaling, circadian rhythm regulation, DNA repair, and cell cycle control. It phosphorylates target substrates to modulate their stability, localization, or interactions, impacting pathways linked to cancer, neurodegenerative diseases, and metabolic disorders.

CSNK1E antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect protein expression, analyze phosphorylation-dependent mechanisms, or map tissue-specific distribution. Researchers employ these antibodies to investigate CSNK1E's involvement in diseases; for example, its overexpression in certain cancers or dysregulation in circadian-related disorders like sleep phase syndromes.

Commercial CSNK1E antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes (e.g., N-terminal or catalytic domains). Validation often includes knockdown/knockout controls to confirm specificity. Challenges may arise due to homology with other CK1 isoforms (e.g., CSNK1D), necessitating careful experimental design. Recent studies also explore CSNK1E inhibitors for therapeutic applications, further driving demand for reliable antibodies in preclinical research. Overall, CSNK1E antibodies are vital for unraveling the protein's biological and pathological significance.