THOC7抗体

The THOC7 antibody is a tool used to study the THOC7 protein, a component of the THO complex, which is part of the larger TREX (Transcription-Export) complex involved in mRNA processing and nuclear export. THOC7. along with other THO subunits (THOC1-THOC7), plays a role in coupling transcription elongation with mRNA splicing, packaging, and transport to the cytoplasm. It is essential for maintaining genome stability and proper gene expression, particularly for long or structured transcripts. THOC7 antibodies are primarily utilized in research to investigate its expression, localization, and interactions in cellular processes, such as cell cycle regulation, differentiation, and stress responses. Dysregulation of THOC7 has been implicated in diseases, including certain cancers and neurodevelopmental disorders. For example, studies suggest its overexpression in leukemia and solid tumors, correlating with poor prognosis. These antibodies are critical in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to explore THOC7’s molecular mechanisms and its role in disease pathways. Their development and validation are vital for advancing understanding of mRNA metabolism defects and potential therapeutic targets.