TSPEAR抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07997(TSPEAR Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07997(TSPEAR Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The TSPEAR (thrombospondin-type laminin G domain and EAR repeats) protein, encoded by the TSPEAR gene, is a poorly characterized extracellular matrix (ECM) component implicated in cell adhesion and tissue development. Structurally, it contains thrombospondin-like and EAR repeat domains, suggesting roles in protein-protein interactions and ECM organization. Research links TSPEAR mutations to autosomal recessive disorders, including nonsyndromic hearing loss (DFNB98) and ectodermal dysplasia-syndactyly syndrome (ECTD-6), highlighting its importance in auditory and ectodermal tissues.

TSPEAR antibodies are critical tools for studying its expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in mapping TSPEAR distribution in tissues such as the inner ear, skin, and hair follicles. These antibodies also facilitate investigations into disease mechanisms, such as disrupted ECM integrity or defective cell signaling in mutation-bearing models. Furthermore, they support therapeutic research, including gene therapy or protein replacement strategies for TSPEAR-related disorders. Despite progress, the precise molecular pathways involving TSPEAR remain unclear, necessitating further antibody-driven studies to elucidate its role in development and disease.