AK2抗体

Adenylate kinase 2 (AK2) is a mitochondrial enzyme involved in cellular energy homeostasis and nucleotide metabolism, facilitating the reversible transfer of phosphate groups between ATP and AMP. It plays a critical role in hematopoietic cell development and immune function. AK2 antibodies are tools used to study its expression, localization, and function in both physiological and pathological contexts. Research has linked AK2 dysfunction to severe human diseases, notably reticular dysgenesis, a rare genetic immunodeficiency disorder characterized by impaired myeloid and lymphoid cell maturation. AK2 antibodies enable detection of protein levels in tissues or cell lines, aiding in diagnostics and mechanistic studies. They are also employed in exploring AK2's role in apoptosis, mitochondrial dynamics, and its interaction with other cellular components. Recent studies suggest AK2 may influence inflammatory responses and cancer progression, expanding its relevance in biomedical research. Commercial AK2 antibodies are typically validated for applications like Western blotting, immunofluorescence, and immunohistochemistry, though variability in specificity requires careful experimental optimization. Ongoing research aims to clarify AK2's broader regulatory networks and therapeutic potential in immune disorders and mitochondrial diseases.