PACSIN2抗体

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P07981(PACSIN2 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07981(PACSIN2 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

PACSIN2 (Protein kinase C and casein kinase substrate in neurons 2), also known as Syndapin-2. is a member of the PACSIN family of cytoplasmic adaptor proteins. It plays a critical role in regulating membrane dynamics, cytoskeletal organization, and intracellular trafficking. Structurally, PACSIN2 contains an N-terminal F-BAR domain that binds to curved membranes, a central SH3 domain mediating protein-protein interactions, and a C-terminal region involved in oligomerization. It interacts with key partners like dynamin, WASP, and N-WASP to facilitate vesicle formation, endocytosis, and actin remodeling.

PACSIN2 antibodies are essential tools for studying its expression, localization, and function in diverse biological contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect PACSIN2 in tissues and cell lines. Research has linked PACSIN2 to neurological processes, cancer progression, and cardiovascular diseases. For example, it modulates synaptic vesicle recycling in neurons and influences cancer cell invasion by regulating matrix metalloproteinase trafficking. Polymorphisms in the PACSIN2 gene have also been associated with hypertension and kidney disease.

Antibody specificity is critical due to homology among PACSIN family members. Validation via knockout controls or siRNA knockdown is often recommended. Commercial PACSIN2 antibodies are typically raised against conserved epitopes, enabling cross-species reactivity. Ongoing studies continue to explore its roles in membrane trafficking disorders and potential therapeutic targeting.