MAPK15抗体

The mitogen-activated protein kinase 15 (MAPK15), also known as ERK8. is a less-characterized member of the MAPK family involved in cellular signaling pathways regulating proliferation, differentiation, and stress responses. Unlike other MAPKs, MAPK15 exhibits unique structural features, including an extended C-terminal region, and has been implicated in diverse processes such as autophagy, cell cycle regulation, and tumorigenesis. Its expression is detected in various tissues, with higher levels observed in the brain, liver, and testes. MAPK15 antibodies are essential tools for studying its expression, localization, and functional roles. These antibodies are typically developed against specific epitopes, such as conserved kinase domains or unique C-terminal sequences, and validated for applications like Western blotting, immunofluorescence, and immunohistochemistry. Research using MAPK15 antibodies has linked its activity to cancer progression, neurodegenerative diseases, and developmental disorders, though its precise mechanisms remain under investigation. Challenges in studying MAPK15 include its low basal expression and context-dependent activation. Reliable antibodies are critical for elucidating its interactions with downstream targets, regulatory pathways, and potential therapeutic applications. Commercial MAPK15 antibodies often undergo validation using knockout cell lines or siRNA-mediated silencing to ensure specificity.