TWF2抗体

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human endometrial carcinoma tissue, A172 cells, U937 cells, Primary antibody: P07962(TWF2 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07962(TWF2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The TWF2 antibody targets Twinfilin-2 (TWF2), a conserved actin-binding protein involved in regulating cytoskeletal dynamics. Twinfilin-2 belongs to the twinfilin family, characterized by two actin-depolymerizing factor (ADF)-homology domains and a C-terminal coiled-coil region. It plays a critical role in cellular processes such as actin filament assembly, disassembly, and trafficking by sequestering actin monomers or capping filament barbed ends. TWF2 is ubiquitously expressed but enriched in tissues with high cytoskeletal remodeling activity, including neurons and cancer cells. Its dysfunction has been linked to impaired cell migration, endocytosis, and tumor metastasis.

The TWF2 antibody is widely used in research to study the protein's expression, localization, and interactions. It aids in detecting TWF2 via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Studies utilizing this antibody have elucidated TWF2's role in diseases, such as cancer progression and neurological disorders, where cytoskeletal dysregulation is a hallmark. Commercial TWF2 antibodies are typically raised against specific epitopes, often in mouse or rabbit hosts, with validation in knockout models to ensure specificity. Ongoing research continues to explore TWF2's regulatory mechanisms and its potential as a therapeutic target.