PIKFYVE抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07961(PIKFYVE Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07961(PIKFYVE Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

PIKFYVE, a lipid kinase encoded by the *PIKFYVE* gene, plays a critical role in regulating intracellular membrane trafficking, autophagy, and ion homeostasis. It synthesizes phosphatidylinositol-3.5-bisphosphate [PI(3.5)P₂] and phosphatidylinositol-5-phosphate [PI(5)P], which are essential for endosomal sorting, lysosomal function, and cytoskeletal dynamics. Dysregulation of PIKFYVE is linked to diverse pathologies, including cancer, neurodegenerative disorders, and viral infections (e.g., SARS-CoV-2 exploits PIKFYVE-dependent pathways for host cell entry).

PIKFYVE antibodies are crucial tools for studying its expression, localization, and molecular interactions. These antibodies typically target specific epitopes within the protein's conserved domains, such as its FYVE zinc finger or kinase regions. Validated antibodies enable applications like Western blotting, immunofluorescence, and immunoprecipitation, aiding in the exploration of PIKFYVE's role in cellular processes and disease mechanisms. Recent research highlights PIKFYVE inhibition as a therapeutic strategy for cancers and COVID-19. spurring demand for high-specificity antibodies to assess target engagement and downstream effects. However, antibody validation remains critical due to potential cross-reactivity with homologous proteins or splice variants. Robust PIKFYVE antibodies are indispensable for advancing both basic research and drug development targeting this enzyme.