PRPSAP1抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07955(PRPSAP1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07955(PRPSAP1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The PRPSAP1 (phosphoribosyl pyrophosphate synthetase-associated protein 1) antibody is a tool used to detect and study the PRPSAP1 protein, which plays a regulatory role in nucleotide biosynthesis. PRPSAP1 interacts with phosphoribosyl pyrophosphate synthetase 1 (PRPS1), a key enzyme in the de novo purine synthesis pathway. This pathway is critical for generating purine nucleotides, essential for DNA/RNA synthesis, energy transfer, and cellular signaling. PRPSAP1 is thought to modulate PRPS1 activity, potentially influencing cellular proliferation and metabolic homeostasis.

Research on PRPSAP1 has linked it to various diseases, including cancer, where dysregulated nucleotide metabolism is a hallmark. Overexpression or mutations in PRPSAP1 may contribute to tumorigenesis by promoting uncontrolled cell growth. Antibodies targeting PRPSAP1 are used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to analyze its expression levels, subcellular localization, and interactions in biological samples. Such studies help elucidate its role in disease mechanisms and metabolic disorders.

Commercially available PRPSAP1 antibodies are typically developed in hosts like rabbits or mice, validated for specificity through knockdown or knockout controls. Their applications extend to basic research, drug development, and biomarker discovery, particularly in contexts involving metabolic reprogramming or oncogenesis. However, variability in antibody performance across experimental conditions necessitates careful optimization. Ongoing research aims to clarify PRPSAP1’s precise regulatory functions and therapeutic potential.