NAT8抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse kidney tissue, Mouse liver tissue, Primary antibody: P07945(NAT8 Antibody) at dilution 1/237.5, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P07945(NAT8 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P07945(NAT8 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

NAT8 (N-acetyltransferase 8), also known as cysteine conjugate N-acetyltransferase, is an enzyme encoded by the NAT8 gene. It belongs to the N-acetyltransferase family and plays a role in metabolic processes, particularly in the acetylation of cysteine S-conjugates and xenobiotic compounds. NAT8 is primarily expressed in the kidney and liver, where it contributes to detoxification pathways and metabolic homeostasis. Dysregulation of NAT8 has been implicated in various pathologies, including renal diseases and cancers, where altered acetylation processes may influence cell proliferation or apoptosis.

NAT8 antibodies are immunological tools developed to detect and quantify NAT8 protein expression in research settings. These antibodies are critical for studying NAT8's biological functions, tissue-specific distribution, and its potential role in disease mechanisms. In cancer research, NAT8 antibodies have been used to investigate its overexpression in certain tumors, such as glioblastoma and renal cell carcinoma, suggesting its possible involvement in tumor metabolism or drug resistance. Additionally, NAT8 antibodies aid in exploring epigenetic regulation, as NAT8 interacts with histone modifiers, linking metabolic activity to chromatin remodeling.

Validated for applications like Western blotting, immunohistochemistry, and immunofluorescence, NAT8 antibodies help identify biomarkers for diagnostic or therapeutic targeting. Recent studies also highlight NAT8's association with neurodegenerative conditions, expanding its relevance beyond metabolic disorders. However, specificity and cross-reactivity challenges require careful validation of these antibodies in experimental models. Overall, NAT8 antibodies serve as vital reagents for unraveling the enzyme's multifaceted roles in health and disease.