ARSG抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07911(ARSG Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07911(ARSG Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

ARGH, or Arylsulfatase G, is a lysosomal enzyme encoded by the *ARSG* gene, belonging to the sulfatase family. It catalyzes the hydrolysis of sulfate esters from glycolipids, glycosaminoglycans, and other substrates, aiding in cellular metabolic recycling. Discovered later than other arylsulfatases (e.g., ARSB, ARSE), ARSG’s biological role remains less characterized. Studies suggest it may contribute to degrading sulfated compounds in lysosomes, with potential links to lysosomal storage disorders (LSDs), though no direct disease association has been conclusively established.

ARSG antibodies are tools used to study the enzyme’s expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry, or immunofluorescence, helping map ARSG distribution in tissues (e.g., liver, kidney) or cellular compartments. Commercial antibodies are typically raised in rabbits or mice against specific peptide epitopes. Research applications include investigating ARSG’s role in sulfatase pathways, substrate specificity, or potential involvement in neurodegenerative or metabolic diseases. However, limited literature and antibody validation pose challenges, necessitating cautious interpretation of results. Ongoing studies aim to clarify ARSG’s physiological and pathological significance, supported by antibody-based assays.