ARSK抗体

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P07910(ARSK Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07910(ARSK Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of ARSK Antibody**

ARSK (Arylsulfatase K) is a member of the sulfatase enzyme family, which catalyzes the hydrolysis of sulfate esters from various substrates, including glycolipids, glycosaminoglycans, and steroids. This enzyme is localized in lysosomes and plays a role in cellular metabolism, particularly in the desulfation of biomolecules, a critical step for their subsequent degradation or functional modification. ARSK shares structural homology with other sulfatases, featuring a conserved active site with a formylglycine residue essential for enzymatic activity.

Biologically, ARSK is implicated in processes such as extracellular matrix remodeling, cellular signaling, and lipid metabolism. Dysregulation of sulfatase activity, including ARSK, has been linked to metabolic disorders, lysosomal storage diseases, and cancer. For example, reduced ARSK expression has been observed in certain cancers, suggesting a potential tumor-suppressive role.

ARSK antibodies are immunological tools designed to detect and quantify ARSK protein levels in research applications. These antibodies enable the study of ARSK’s expression patterns, subcellular localization, and involvement in disease pathways. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies utilizing ARSK antibodies have explored its interaction with metabolic pathways, its role in tissue homeostasis, and its potential as a biomarker or therapeutic target. The development and validation of high-specificity ARSK antibodies continue to support advances in understanding sulfatase biology and related pathologies.