ARMCX3抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: A172 cells, K562 cells, mouse pancreas tissue, Primary antibody: P07895(ARMCX3 Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07895(ARMCX3 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The ARMCX3 (Armadillo repeat-containing X-linked protein 3) antibody is a tool used to study the ARMCX3 protein, a member of the ARMCX family implicated in mitochondrial dynamics and cellular processes. ARMCX3. located on the X chromosome, encodes a protein with six predicted transmembrane domains and Armadillo repeats, suggesting roles in protein-protein interactions or membrane-associated functions. While its exact biological role remains under investigation, ARMCX3 is hypothesized to regulate mitochondrial transport, morphology, or metabolism, particularly in neurons, given its homology to other mitochondrial proteins. Dysregulation of ARMCX3 has been linked to neurological disorders and cancers, such as glioblastoma, where it may influence tumor progression via metabolic pathways.

ARMCX3 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies enable detection of ARMCX3 in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validation often includes confirming specificity through knockout/knockdown cell lines or tissue samples. Researchers utilize these antibodies to explore ARMCX3's expression patterns, subcellular localization (e.g., mitochondrial association), and interactions with signaling pathways. As ARMCX3 is part of a larger protein family with overlapping functions, careful experimental controls are essential to distinguish its role from related proteins like ARMCX1 or ARMCX5. Its study contributes to understanding mitochondrial biology and disease mechanisms.