WNT11抗体

The Wnt11 antibody is a research tool designed to detect and analyze the Wnt11 protein, a member of the Wnt family of secreted signaling molecules. Wnt11 plays critical roles in embryonic development, tissue morphogenesis, and cell polarity regulation, primarily through non-canonical Wnt pathways, such as the planar cell polarity (PCP) and Wnt/calcium pathways. Dysregulation of Wnt11 has been implicated in developmental defects, cancer progression, cardiovascular disorders, and fibrosis. The antibody enables researchers to study Wnt11 expression, localization, and interactions in various biological contexts using techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Commercial Wnt11 antibodies are typically raised in hosts such as rabbits or mice, targeting specific epitopes within the protein’s conserved domains. Validation often includes knockout controls or siRNA-based silencing to confirm specificity. Challenges include cross-reactivity with related Wnt proteins (e.g., Wnt5a) due to structural homology, necessitating careful experimental optimization. Wnt11 antibodies are essential for investigating its role in cell migration, tissue repair, and disease mechanisms, with potential applications in diagnostics and therapeutic development. Recent studies also explore its involvement in stem cell differentiation and organoid models, highlighting its versatility in biomedical research.