ARHGAP1抗体

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P07880(ARHGAP1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The ARHGAP1 antibody is a crucial tool for studying the ARHGAP1 protein, a member of the Rho GTPase-activating protein (RhoGAP) family. ARHGAP1. also known as p50-RhoGAP, functions as a negative regulator of Rho GTPases, including RhoA, Rac1. and Cdc42. by accelerating their GTP hydrolysis, thereby switching them to an inactive GDP-bound state. This regulatory mechanism influences cytoskeletal dynamics, cell adhesion, migration, and polarity. ARHGAP1 is ubiquitously expressed and plays roles in diverse cellular processes such as cytokinesis, vesicle trafficking, and cell cycle progression. Dysregulation of ARHGAP1 has been implicated in pathological conditions, including cancer metastasis, neurodegenerative disorders, and cardiovascular diseases, due to its impact on Rho signaling pathways.

Antibodies targeting ARHGAP1 are widely used in research to detect protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. They help elucidate ARHGAP1’s functional roles in cellular models and disease contexts. For instance, studies using ARHGAP1 antibodies have revealed its involvement in tumor cell invasion by modulating RhoA activity, as well as its contribution to neuronal development through cytoskeletal remodeling. Commercial ARHGAP1 antibodies are typically validated for specificity against conserved regions, such as the N-terminal or C-terminal domains. Researchers rely on these reagents to explore therapeutic targets linked to RhoGAP-mediated signaling cascades, making ARHGAP1 antibodies essential for advancing mechanistic insights into cell biology and disease pathogenesis.